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Molnupiravir news   All Outcomes
11/6 Review
Goldstein, L., TrialSite News (Review) (News)
Molnupiravir: mutagenic, carcinogenic, authorized in the UK
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Discussion of concerns with molnupiravir and the MOVe-OUT trial. Author notes that results showing bone marrow toxicity in dogs were mentioned in this preprint [1], but removed from the journal version [2]. Some additional details were provided by the UK regulator:
“Reversible, dose-related bone marrow toxicity affecting all haematopoietic cell lines was observed in dogs at ≥17 mg/kg/day (0.4 times the human NHC exposure at the recommended human dose (RHD)).” [3]
For those without TrialSite News access, this article can also be found at [4].
Goldstein et al., 11/6/2021, preprint, 1 author.
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