News release reporting interim analysis of the MOVe-OUT trial, showing significantly lower risk of hospitalization or death. NCT04575597
Merck et al., 10/1/2021, Randomized Controlled Trial, multiple countries, multiple regions, preprint, 1 author.
risk of death, 94.2% lower, RR 0.06, p = 0.003, treatment 0 of 385 (0.0%), control 8 of 377 (2.1%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of combined hospitalization/death, 48.3% lower, RR 0.52, p = 0.001, treatment 28 of 385 (7.3%), control 53 of 377 (14.1%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.