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All Studies   All Outcomes    Recent:   
0 0.5 1 1.5 2+ Viral clearance 58% Improvement Relative Risk Molnupiravir  Optimus et al.  EARLY TREATMENT  RCT Is early treatment with molnupiravir beneficial for COVID-19? RCT 355 patients in India Improved viral clearance with molnupiravir (p<0.000001) c19early.org Optimus, Press Release, July 2021 Favors molnupiravir Favors control

Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India

Optimus, Press Release
Jul 2021  
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Interim report on CTRI/2021/06/033992, showing faster viral clearance. Event counts are approximate, the press release only provides percentages.
Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer Chamod, Hadj Hassine, Huntsman, Marikawa, Swanstrom, Waters, Zhou, Zibat. Multiple analyses have identified variants potentially created by molnupiravir Fountain-Jones, Kosakovsky Pond, Sanderson, twitter.com.
risk of no viral clearance, 58.0% lower, RR 0.42, p < 0.001, treatment 38 of 175 (21.7%), control 93 of 180 (51.7%), NNT 3.3, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Optimus et al., 21 Jul 2021, Randomized Controlled Trial, India, preprint, 1 author.
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