Wong, 10,512 patient molnupiravir late treatment PSM study: 45% lower mortality [p<0.0001], 69% lower ventilation [p=0.0006], 47% lower combined mortality/ICU admission [p<0.0001], and no change in hospitalization [p=0.86] https://c19p.org/wong3
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Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir among COVID-19 inpatients during Hong Kong’s Omicron BA.2 wave: an observational study
et al., medRxiv, doi:10.1101/2022.05.19.22275291 (Preprint)
PSM retrospective 40,776 hospitalized patients in Hong Kong, showing lower mortality and mechanical ventilation with molnupiravir treatment.Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom].
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risk of death, 45.0% lower, HR 0.55, p < 0.001, treatment 2,116, control 8,396, propensity score matching.
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risk of mechanical ventilation, 69.0% lower, HR 0.31, p < 0.001, treatment 2,116, control 8,396, propensity score matching.
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combined death/ventilation/ICU, 47.0% lower, HR 0.53, p < 0.001, treatment 2,116, control 8,396, propensity score matching.
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hospitalization time, 0.5% lower, relative time 1.00, p = 0.86, treatment 2,116, control 8,396, propensity score matching.
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Ct<30, 17.4% lower, HR 0.83, p = 0.003, treatment 2,115, control 8,396, propensity score matching.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Wong et al., 5/20/2022, retrospective, China, Asia, preprint, 6 authors, study period 26 February, 2022 - 26 April, 2022.
Contact:
carlosho@hku.hk, bcowling@hku.hk.
Late treatment
is less effective
is less effective
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