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Home   COVID-19 treatment studies for Molnupiravir  COVID-19 treatment studies for Molnupiravir  C19 studies: Molnupiravir  Molnupiravir   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -282% Improvement Relative Risk Mortality (b) -217% Mortality (c) -317% Mortality (d) -311% Recovery 1% Recovery (b) 12% Recovery (c) -1% Recovery time 0% no CI Recovery time (b) 0% no CI Recovery time (c) 0% no CI Virological cure 12% Virological cure (b) -2% Virological cure (c) 21% Virological cure (d) 8% Virological cure (e) -48% Virological cure (f) 21% c19mp.com/arribas.html Favors molnupiravir Favors control
16 December 2021 - Late treatment study
Randomized Trial of Molnupiravir or Placebo in Patients Hospitalized with Covid-19
Arribas et al., NEJM Evidence, doi:10.1056/EVIDoa2100044 (Peer Reviewed)
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RCT 304 hospitalized patients, 218 treated with molnupiravir, showing no significant differences. MOVe-IN MK-4482-001. NCT04575584.
risk of death, 281.9% higher, RR 3.82, p = 0.31, treatment 11 of 216 (5.1%), control 1 of 75 (1.3%), combined, excluding imputed deaths.
risk of death, 216.9% higher, RR 3.17, p = 0.36, treatment 3 of 71 (4.2%), control 1 of 75 (1.3%), 800mg, excluding imputed death.
risk of death, 316.7% higher, RR 4.17, p = 0.20, treatment 4 of 72 (5.6%), control 1 of 75 (1.3%), 400mg, excluding imputed death.
risk of death, 311.0% higher, RR 4.11, p = 0.21, treatment 4 of 73 (5.5%), control 1 of 75 (1.3%), 200mg.
risk of no recovery, 1.0% lower, RR 0.99, p = 0.96, treatment 72, control 75, 800mg.
risk of no recovery, 11.5% lower, RR 0.88, p = 0.53, treatment 73, control 75, 400mg.
risk of no recovery, 1.0% higher, RR 1.01, p = 0.96, treatment 73, control 75, 200mg.
recovery time, no change, relative time 1.00, treatment 72, control 75, 800mg.
recovery time, no change, relative time 1.00, treatment 73, control 75, 400mg.
recovery time, no change, relative time 1.00, treatment 73, control 75, 200mg.
risk of no virological cure, 11.8% lower, RR 0.88, p = 0.57, treatment 26 of 52 (50.0%), control 34 of 60 (56.7%), NNT 15, 800mg, Table S16, day 15 mid-recovery.
risk of no virological cure, 2.4% higher, RR 1.02, p = 1.00, treatment 29 of 50 (58.0%), control 34 of 60 (56.7%), 400mg, Table S16, day 15 mid-recovery.
risk of no virological cure, 20.6% lower, RR 0.79, p = 0.27, treatment 27 of 60 (45.0%), control 34 of 60 (56.7%), NNT 8.6, 200mg, Table S16, day 15 mid-recovery.
risk of no virological cure, 8.3% lower, RR 0.92, p = 1.00, treatment 9 of 53 (17.0%), control 10 of 54 (18.5%), NNT 65, 800mg, Table S16, day 29.
risk of no virological cure, 48.2% higher, RR 1.48, p = 0.35, treatment 14 of 51 (27.5%), control 10 of 54 (18.5%), 400mg, Table S16, day 29.
risk of no virological cure, 21.5% lower, RR 0.79, p = 0.61, treatment 8 of 55 (14.5%), control 10 of 54 (18.5%), NNT 25, 200mg, Table S16, day 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Arribas et al., 12/16/2021, Double Blind Randomized Controlled Trial, multiple countries, multiple regions, peer-reviewed, 21 authors, average treatment delay 7.1 days.
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